Introducing Engineered Disease State Plasma
Finding a sustainable supply of disease state plasma (DSP) for control, calibrator and EQC manufacturing can be a challenge. Our team of experts are tackling this challenge head on, focussing on hard to source bulk disease state plasma unmet needs.
- Engineered DSP will replicate native disease state plasma
- Minimise changes in customer workflow and ease transition from native
- Provide a long-term sustainable supply of high-quality disease state material
- Deliver lot to lot reproducibility
Engineered DSP Development
With a unique combination of bulk protein purification, Human FC monoclonal antibody and customer application expertise, Logical Biological is perfectly positioned to develop engineered disease state materials.
- Stable Human Fc Ab performance
- Immortalized plasmacytes express naturally the chaperone, J chain and secretion system of specialised immune system cells
- 100% correctly folded antibodies with all the post-translational modifications needed to have active antibodies
- Disease State Plasma characteristics
- Replicating critical plasma characteristics, using plasma matrix, depletion, concentration
- Relevant performance data
- Tested on multiple platforms against a relevant disease state plasma control to generate relevant performant data
March 19th 2025
When it comes to manufacturing quality controls (QCs), choosing the right raw material is essential. With factors like supply sustainability, cost, and performance to be considered, how do you decide whether a native or synthetic biological raw material is best?
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