Logical Biological is dedicated to fostering sustainability, operating with ethics and integrity, and striving to reduce our environmental footprint. In-fact one of our 6 company values set down as the founding principles of our company is “We do we what we can to reduce our environmental impact.” This principle is deeply embedded in our company culture, influencing our daily activities, and guiding our efforts towards creating a more sustainable future for everyone.

 

Our Carbon Offsetting Journey

Early in 2023 we made a firm commitment to carbon offset all our incoming and outgoing freight and set about measuring our carbon tonnage. Throughout the year this goal expanded, and we increased our commitment to include our carbon tonnage (Scopes 1 & 2) for the following;

  • Freight for all shipments
  • Business Travel
  • Staff Commuting
  • Office Lab equipment (electrical usage etc)
  • Office and Lab Space lighting etc
  • Dry Ice

We opted to work with Native, a US based public benefit and certified B corporation, to ensure our carbon offsets achieve our company’s sustainability goals, which are based on the 17 UN Sustainable Development Goals (SDGs).

We are proud to announce that we have offset our carbon impact and are carbon neutral for the above activities in 2023.

 

Sustainability Projects we are Supporting

We have offset our 2023 carbon footprint by purchasing verified emissions reductions’ credits (VER’s) to support 2 projects for the next 20 years;

  1. Brazil Pastureland Regeneration project

The Brazil Pastureland Regeneration with Native Palm Silvopasture Project works with smallholder farms in Brazil to plant native Macaúba palms in degraded pasturelands. This work will create a silvopasture system that sequesters carbon in the soil, provides shade for grazing livestock, and supports biodiversity, while providing a responsibly grown source of palm. It will remove >900,000 tCO2e over 20 years and have a substantial impact on the community by providing additional income for 100+ farms and jobs for over 300 people.

  1. Mozambique Clean Water project

The Mozambique Clean Drinking Water Project, led by the non-profit Village Water, rehabilitates, installs, and maintains borehole water infrastructure to provide communities with safe, clean drinking water. The project also;

  • builds capacity and offers training at the local level around managing water sources into the future.
  • reduces the risk of waterborne illnesses and the need to boil water for purification, which saves over 95,000 tonnes of firewood annually and reduces CO2 emissions.
  • improves sanitation and hygiene practices in the communities.
  • allows women and girls to spend more time on other activities previously dedicated to collecting water and firewood.

As a result of this project to date, over 36,000 people have access to clean drinking water, and over 98 million litres of drinking water are supplied annually.

 

2023 Sustainable Development Goal Achievements

Reducing inequalities was also part of our 2023 sustainability goals. In February 2023, we sought your insights through our customer satisfaction survey. In response to each completed survey, we made donations to PATH, an international organization dedicated to advancing health equity worldwide. Your participation not only aided our sustainability endeavors but also supported a specific Sustainable Development Goal. We are grateful for your valuable contribution to this vital cause.

Sustainability achievements 2023

Sustainability Programs in the Local Community

We are active members of the local community where we are based, Discovery Park. Annually, we plant Christmas Trees on-site, fostering a green initiative. Additionally, we’ve launched an on-site program for the collection and recycling of printer toner cartridges in Feb 2023.

Christmas Trees growing
Last year’s Christmas Trees

We reuse packaging materials including expanded polystyrene (EPS) boxes, dry ice, and cool packs. Over the last 4 years we have re-used 41% of our EPS boxes for our outgoing shipments.

Logical Biological supports volunteer days and we have an annual volunteer day. In March 2023 we volunteered our time to the Kent Wildlife Trust and spent the day at Sandwich and Pegwell Bay, litter picking and clearing sea-buckthorn which dominates the dunes above the bay. To read more please see our blog.

 

Our Sustainability Credentials

In April 2023 we were awarded a Bronze EcoVadis Medal. EcoVadis measures the quality of a company’s sustainability management system and will be planting a tree on our behalf. Our objective is to consistently improve our performance to attain a higher rating in the 2024 assessment.

EcoVadis Bronze 2023

2024 Sustainability Plan

Our 2024 Sustainability Plan is an extension of our achievements from 2023 and we will continue to review our progress, reinforcing our dedication to environmental stewardship and sustainable business practices. Concentrating on key areas— Environment, Labour and Human Rights, and Ethics — we not only aim to enhance our EcoVadis score significantly, but we are also steadfast in our goal to achieve Carbon Neutrality in 2024 by once again minimising and offsetting all carbon emissions.

Calprotectin is a heterodimer protein expressed by leucocytes and used as a biomarker for Inflammatory Bowel Disease (IBD). It is packed into granular neutrophils (up to 60% of cytoplasmic protein) and released by shedding, active secretion, or cell death. Calprotectin is present in IBD patients because it is expressed by leucocytes that have accumulated in the gastrointestinal tract as part of the inflammatory response and is therefore present in the faeces when intestinal inflammation occurs.

Why measure Calprotectin?

The use of Calprotectin screening has dramatically altered diagnosis of IBD diseases, such as Crohn’s disease and ulcerative colitis. It is considered a reliable marker because it is resistant to degradation and samples can be kept for up to 5 days without affecting tests or results. Calprotectin can be used as a screening tool to differentiate between IBD and Irritable Bowel Syndrome (IBS) and prevent unnecessary endoscopies for patients with low Calprotectin levels. This is a relief to most and makes significant cost savings for healthcare payors, however an endoscopy is still recommended to diagnose patients with suspected IBD based on the UK, Canadian, World and US Gastroenterology Organization guidelines. With an increasing amount of young people, and children being diagnosed with IBD alternatives to invasive tests are vital.

If a patient presents with symptoms of lower abdominal pain, it is important to ascertain between a range of illnesses. Early symptoms of IBD are very similar to IBS. A short list of associated symptoms include:

  • Abdominal pain and discomfort
  • Irregular bowel movements
  • Irregular bowel consistencies
  • Nausea
  • Bloating

If IBD progresses bleeding, anaemia, weight loss and fever can occur. The causes of IBD versus IBS are very different and differentiating between the two is important for patient care.

Calprotectin tests

Calprotectin levels can be measured through faecal sampling via a variety of testing methodologies. From rapid immunochromatographic (also known as lateral flow) tests, enzyme-linked immunosorbent assays (ELISA), and automated immunoassays, there are tests to suit all situations, from home testing to larger scale laboratory testing. All provide quantitative results, however measurements exhibit variability and no current method is universally accepted as a standard.

 

The reference ranges for calprotectin levels can vary slightly between different laboratories and assay methods and each manufacturer sets their own cut-off values for IBD and IBS differentiation. Calprotectin Stool samples In the UK, many hospitals are using the New Faecal Calprotectin Care Pathway for interpretation of the values obtained from a faecal calprotectin test with the following criteria:

  • <100µg/g = IBD is unlikely
  • 100 – 250µg/g = Intermediate result – Repeat the test in 2 weeks
  • >250µg/g = Likely IBD refer to secondary care

It is important to note that this pathway is based on testing using the Bühlmann assay, with some compatibility testing performed to understand the cut off differences for the Thermo Fisher assay. It is essential that users are aware of which testing option they are utilizing to ensure the most effective outcomes in their chosen care pathways.

Tracking Calprotectin levels throughout the course of an IBD suffered illness is increasingly aiding treatment decisions. The move from lab-based ELISA to home-based lateral flow tests initiated  a study comparing 3 lateral flow tests utilising a smart phone app with known ELISA tests to confirm Calprotectin levels. All three calprotectin home tests and companion ELISAs agreed sufficiently when concentrations were at the high end (≤500 μg/g).

Calprotectin Conclusion

Calprotectin testing has reduced the numbers of endoscopies and colonoscopies required, saving time, money, and patient discomfort. Used in isolation preliminary Calprotectin tests may well have limitations, but in conjunction with full medical history and other diagnostic procedures it is a useful tool to differentiate between IBD and IBS. Using Calprotectin tests throughout the course of a sufferers IBD could help the patient manage their lifestyle and treatments. Aided by the use of smart phone apps that facilitate test readings and can link directly with GP surgeries. International standardisation remains an issue and is something for manufacturer collaboration to resolve.

Logical Biological Products

Logical Biological offers stools/faeces from donors, including those diagnosed with IBD, containing known levels of Calprotectin measured using the Diasorin Liaison test or Bühlmann fCAL® ELISA. This material is suitable for many applications including assay development, assay validation, quality control testing and External Quality Assurance schemes.